Billionaire investor Isaacman has been formally approved as the new administrator of NASA, ending an extraordinary selection saga where President Donald Trump nominated him, withdrew it, and then put him forward again.
The billionaire, an amateur jet pilot who was the first non-professional astronaut to perform a extravehicular activity, is also the first agency head in decades to come entirely from the private sector.
For a significant portion of the space community, the success of his time in office will be decided by one pivotal challenge: whether it can return humans to the lunar surface before the Chinese space program.
The President has made clear a goal for the US to build a permanent lunar base, both to allow for harvesting materials and to serve as a staging point for travel to the Red Planet.
On This week, the Senate approved the nomination with a bipartisan vote.
The President first withdrew Isaacman's nomination in the spring, citing a "thorough review of prior associations".
At the point, the president was engaged in a dispute with Elon Musk, one of his biggest supporters, with whom Isaacman has a working relationship.
The new administrator has stated he is now completely supportive of Trump's mission to mine the moon, putting him at odds with Musk, who has stated that going to the Moon is a distraction from the goal of travelling to Mars.
In the present cosmic competition, nations are vying to exploit the lunar surface.
“Now is not the time for hesitation but a time for action because if we fall behind, if we make a mistake, we may not recover, and the results could change the balance of power here on our planet,” Isaacman told the Senate committee recently.
The private sector veteran sees introducing more industry players as crucial for accomplishing those objectives, according to a circulated document detailing his strategy for the agency.
In his Senate hearing, he supported the strategy, which he drafted when he was initially selected, but said it was a work in progress.
His openness to multiple providers could also create a conflict with SpaceX. Last week, he praised the granting of a major contract to Blue Origin, which is one of the primary competitors of Musk's SpaceX.
In the strategy paper, he recommended NASA should expand collaboration with universities and academic institutions, casting the agency as a "catalyst for scientific discovery".
He pointed to the scheduled deployment of the Nancy Grace Roman Space Telescope as a cornerstone project.
"Should we be on the verge of something extraordinary - like deploying the Roman Telescope - I will explore every option to get the program to the pad, even using my own resources if that's what it takes to deliver the science," he stated.
According to analyses, his fortune is valued at approximately $1.2bn, made mostly from his financial services firm and the sale of his business that trained pilots and operated a collection of military jets.
The top job at NASA will be his first job in government service, a departure from the last two people appointed as head of the agency.
He will take over from Sean Duffy, who has been the acting administrator since the summer.